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Even though no sizeable distinctions had been located in tyrosine hydroxylase action and expression, brain tissue levels of 3,4-dihydroxyphenylalanine were being threefold bigger in α2A- and α2C-adrenoceptor KO mice. Brain tissue amounts of dopamine and noradrenaline had been substantially greater in α2A and α2CKOs in comparison with WT [WT: tw